7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Short Description:

Name: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2

Purity: >99.0% (HPLC)

Appearance: Light Yellow to Light Brown Powder

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Send email to us

Product Detail

Product Tags

Description:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine CAS 314771-88-5

Chemical Properties:

Chemical Name	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Synonyms	7-Chloro-4-Hydroxy-6-Nitroquinazoline; 7-Chloro-6-Nitro-4-Quinazolinol; 7-Chloro-6-Nitro-4-Quinazolinone; 7-Chloro-6-Nitro-4(3H)-Quinazolinone; 7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-one; 7-Chloro-6-Nitroquinazolin-4(3H)-one
CAS Number	53449-14-2
CAT Number	RF-PI2030
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C8H4ClN3O3
Molecular Weight	225.59
Sensitivity	Heat Sensitive
Solubility	Slightly Soluble in Dimethylformamide
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Light Yellow to Light Brown Powder
Identification (HPLC)	Retention Time of Sample Should Matches with Standard
Purity / Analysis Method	>99.0% (HPLC)
Melting Point	300.0~303.0℃
Water Content (K.F)	<0.50%
Residue on Ignition	<0.30%
Impurity 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
Impurity 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
Impurity 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Other Single Impurity	<0.20%
Total Impurities	<1.00%
Heavy Metals (as Pb)	<20ppm
Infrared Spectrum	Conforms to Structure
Proton NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Usage	Intermediate of Afatinib, Afatinib Dimaleate

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) is an intermediate of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib is an irreversible ErbB family of blockers that suppress information transmission and block the major pathways involved in cancer cell growth and division. Because ErbB family information transduction mechanism can be triggered by multiple homodimers and heterodimers, simultaneous inhibition of multiple ErbB family members (such as EGFR, HER2, ErbB3 and ErbB4) can effectively interrupt the downstream information transduction. Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal receptor-EGFR) in some tumors.